Reino Laatikainen, Ph.D.

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on 2000 -

off 1990 - 1999

off 1980 - 1989

off 1970 - 1979

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PUBLICATIONS 2000 -

Articles in international scientific journals with referee practice.

  • 101. Toivanen M, Huttunen S, Duricová J, Soininen P, Laatikainen R, Loimaranta V, Haataja S, Finne J, Lapinjoki S, Tikkanen-Kaukanen C, Screening of binding activity of Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus suis to berries and juices, Phytotherapy Research, 2009, in press.
  • 100. Lehtivarjo J, Hassinen T, Korhonen S-K, Peräkylä M, Laatikainen R, 4D prediction of protein 1H chemical shifts, J Biomol NMR (2009), in press.
  • 99. Tiainen, M, Maaheimo, H Soininen, P, Laatikainen, R, 13C Isotope Effects on 1H Chemical Shifts: NMR Spectral Analysis of 13C-Labelled D-glucose and Some 13C-Labelled Amino Acids, Magn.Reson.Chem. (2009), in press.
  • 98.  Hanhineva K, Soininen P, Anttonen MJ, Kokko H, Rogachev I, Aharoni A, Laatikainen R,, Kärenlampi SO, NMR and UPLC-qTOF-MS/MS Characterisation of Novel Phenylethanol Derivatives of Phenylpropanoid Glucosides from the Leaves of Strawberry (Fragaria × ananassa cv. Jonsok), Phytochem.Anal. (2009), in press.
  • 97.  Soininen P, Kangas AJ, Wurtz P, Tukiainen T, Tynkkynen T, Laatikainen R, Järvelin M-R, Kähönen M, Lehtimäki T, Viikari J, Raitakari, OT, Savolainen MJ, Ala-Korpela M, High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism, Analyst (2009) 134, 1781–1785.
  • 96.  Tynkkynen T, Soininen P, Tiainen M, Laatikainen R, From proton nuclear magnetic resonance spectra to pH. Assesment of 1H NMR pH indicator compound set for deuterium oxide solutions, Anal.Chim.Acta(2009), 648, 105-112.
  • 95.  Taru Tukiainen, Tuulia Tynkkynen, Ville-Petteri Mäkinen, Pasi Jylänki, Antti Kangas, Johanna Hokkanen, Aki Vehtari, Olli Gröhn, Merja Hallikainen, Hilkka Soininen, Miia Kivipelto, Per-Henrik Groop, Kimmo Kaski, Reino Laatikainen, Pasi Soininen, Tuula Pirttilä, Mika Ala-Korpela, A multi-metabolite analysis of serum by 1H NMR spectroscopy: Early systemic signs of Alzheimer’s disease, Biochem.Biophys.Res.Commun. (2008), 375, 356-361.
  • 94.  Repo S, Jyrkkärinne J, Pulkkinen JT, Laatikainen R, Honkakoski P, Johnson MS Ligand Specificity of Constitutive Androstane Receptor as Probed by Induced-fit Docking and Mutagenesis, J.Med.Chem. (2008), 51, 7119-7131.
  • 93.  Pulkkinen JT, Honkakoski P, Peräkylä M, Berczi I, Laatikainen R, Synthesis and Evaluation of Estrogen Agonism of Diaryl 4,5-Dihydroisoxazoles, 3-Hydroxyketones, 3-Methoxyketones and 1,3-Diketones: A Compound Set Forming a 4D Molecular Library, J.Med.Chem. (2008), 51, 3562-3571.
  • 92.  Jukarainen, N.M., Korhonen, S-P., Laakso, M.P., Korolainen, M.A., Niemitz, M., Soininen, P., Tuppurainen, K., Vepsäläinen, J., Pirttilä, T., Laatikainen, R., Quantification of 1H NMR Spectra of Human Cerebrospinal Fluid: A Protocol Based on Constrained Total-Line-Shape Analysis, Metabolomics (2008), 4, 150-160.
  • 91.  Mika Tiainen, Hannu Maaheimo, Matthias Niemitz, Pasi Soininen and Reino Laatikainen, Spectral Analysis of 1H Coupled 13C Spectra of the Amino Acids: Adaptive Spectral Library of Amino Acid 13C Isotopomers, Magn.Reson.Chem. (2008), 46, 125-137.
  • 90.  P. Soininen, K. Öörni, H. Maaheimo, R. Laatikainen, P.T. Kovanen, K. Kaski, M. Ala-Korpela, 1H NMR Spectroscopy at 800 MHz Resolves Lysophosphatidylcholine from hosphatidylcholine and Sphingomyelin in Low Density Lipoprotein Particles and Facilitates Detailed Phospholipid Follow-Up During Atherogenic Modifications, Biochem.Biophys.Res.Commun. (2007), 360, 290–294.
  • 89.  Niemitz, M., Laatikainen, R.,Chen, S-N., Kleps, R., Kozikowski, A., Pauli, G.F., Complete 1H NMR Spectral Fingerprint of Huperzine A, Magn.Reson.Chem. (2007), 45, 878-882.
  • 88.  Ala-Korpela, M., Lankinen, N., Salminen, A., Suna, T., Soininen, S., Laatikainen, R., Ingman, P., Jauhiainen, M., Taskinen, M-R., Heberger, K. Kaski, K., The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent, Atherosclerosis, (2007), 190, 353-358.
  • 87.  Malm, T., Ort, M., Tähtivaara, L., Jukarainen, N., Goldsteins, G., Puoliväli, J., Nurmi, A., Pussinen, R., Ahtoniemi, T., Miettinen, T-K., Kanninen, K., Leskinen, S., Vartiainen, N.,Yrjänheikki, J., Laatikainen, R., Harris-White, M.E., Koistinaho, M., Frautschy, S.A., Bures, J., Koistinaho, ß-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or ß-amyloid deposits, Proc.Natl Acad.Sci.USA (2006), 103, 8853.
  • 86.  Korhonen, S-P., Tuppurainen, K., Laatikainen, R., Peräkylä, M., Comparing the Performance of FLUFF-BALL to SEAL-COMFA with a Large Diverse Estrogen Data Set: from Relevant Superpositions to Solid Predictions, J.Chem.Inf.Model. (2005) 45, 1874-883.
  • 85.  Koistinen, K.M., Soininen, P., Venäläinen, T., Häyrinen J., Laatikainen, R., Peräkylä, M., Tervahauta, A., Kärenlampi, S., Birch Pr-10c interacts with several biologically important ligands, Phytochemistry (2005) 66, 2524-2533.
  • 84. Soininen, P., Haarala, J., Vepsäläinen, J., Niemitz, M., Laatikainen, R., Strategies for Organic Impurity Quantification by 1H NMR spectroscopy: Constrained Total-Line-Shape Fitting, Anal.Chim.Acta, (2005), 542, 178-185.
  • 83. Tuppurainen, K., Viisas, M., Peräkylä, M., Laatikainen, R., Ligand Intramolecular Motions in Ligand-Protein Interaction: ALPHA, a Novel Dynamic Descriptor and a QSAR Study with Extended Steroid Benchmark Dataset. J.Mol.Design, 18, 175-187 (2004).
  • 82. Pulkkinen, J., Zachar, P., Borek, V.A., Laatikainen, R., Kral, V., Application of novel metallocomplexes for mimicking of cytochrome P450. Analysis of product distribution for 1-hexene as a substrate. Journal of Molecular Catalysis A, 219, 21-27 (2004).
  • 81. Seppänen, K., Soininen, P., Salonen, J.T., Lötjönen, S., Laatikainen, R., Does Mercury Promote Lipid Peroxidation? An In Vitro Study Concerning Mercury, Copper and Iron in Peroxidation of Low Density Lipoprotein. Biological Trace Element Research,57, 84-87 (2004).
  • 80. Elomaa, M., Asplund, A., Soininen, P., Laatikainen, R., Peltonen, S., Hyvärinen, S., Urtti, A., Determination of the degree of substitution of acetylated starch by hydrolysis, 1H NMR and TGA/IR. Carbohydrate Polymers,57, 261-267 (2004).
  • 79. Korhonen, S-P, Tuppurainen, K., Laatikainen, R., Peräkylä, M., FLUFF-BALL, A Template-Based Grid-Independent Superposition and QSAR Technique: Validation Using Benchmark Steroid Data Set. J.Chem.Inf.Comput.Sci.,43, 1780-1793 (2004).
  • 78. Airaksinen, A.J., Lipsonen, J., Ahlgren, M., Vainiotalo, P., Bergström, K.A., Laatikainen, R., Vepsäläinen, J., Reduction of 6/7-substituted 3-phenyltrop-3-en-2-ones: stereoselectivity and conformational analysis of the products. Tetrahedron, 59, 377-383 (2003).