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Project Objectives

The co-ordinated activities of the nuclear receptor (NR) transcription factor family orchestrate responses to environmental factors by sensing a diverse range of dietary and xenobiotic components. The main goal of this project is to define key components of the NR gene regulatory network that facilitate this process and model their impact on the development of aging-related syndromes and pathologies, such as carcinogenesis, metabolic syndromes, osteoporosis and skin aging. The aims of the Consortium are:

I.  to use interdisciplinary expertise in applying standardized protocols to study the impact of dietary sensing by NRs on the genome, epigenome, transcriptome, proteome, metabolome and physiome, and thereby model these actions in different human tissues.
 

II.  to use intersectorial expertise in revealing the significance of NR-nutrient signaling in pathological conditions associated with aging, such as carcinogenesis, metabolic syndromes, osteoporosis and aging skin.
 

III.  to generate an interdisciplinary and intersectorial understanding using systems biology modelling with the aims of i) revealing a predicative and preventative ultimately personalized paradigm for the effect of diet upon key aspects of health within the aging European population and ii) generating commercial realization.

NucSys:  Systems biology of nuclear receptors: A nutrigenomic approach to aging-related diseases