Theses

94 Sari Rastas: Vascular risk factors in the very old with emphasis on mortality and cognition. 2009.
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93 Alina Solomon: Cholesterol and late-life cognition. An epidemiological and clinical approach. 2009.
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92 Anna Hicks: Intracerebral stem cell transplantation in experimental stroke models. 2009.
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91 Anne Jauhiainen: Functional and structural magnetic resonance imaging studies in mild cognitive impairment and Alzheimer's disease. 2008.
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90 Saila Vepsäläinen: A molecular genetic study and expression-based analysis of risk factors of Alzheimer's disease. Emphasis on amyloid beta degrading enzymes, IDE and NEP. 2007.
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89 Heli Karhunen: Long-term studies of epileptogenesis after focal cerebral ischemia in rats. 2007.
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88 Sanna-Kaisa Herukka: Usefulness of cerebrospinal fluid biomarkers in diagnosis of early Alzheimer's disease. 2007.
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87 Katriina Viinikainen: Epilepsy, female reproductive health and neurodevelopment of the offspring. 2007.
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86 Jari Huuskonen: Microglial response to inflammatory stimuli-impact of protein acetylation and phosphorylation. 2007. 
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85 Corina Pennanen: Brain atrophy in Mild Cognitive Impairment: MRI volumetric and voxel-based method study. 2006.
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84 Petri Kerokoski: Regulation of cyclin-dependent kinase-5 (Cdk5) with special emphasis on changes occurring during neuronal cell death. 2006.
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83 Minna Korolainen: Proteomic analysis of post-translationally modified proteins in Alzheimer's disease. 2006.
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82 Taneli Heikkinen: Cognitive effects of estrogen in ovariectomized, aged and transgenic mice modeling Alzheimer’s disease. 2006.
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81 Anne Koivisto: Genetic components of late-onset Alzheimer's disease with special emphasis on ApoE, IL-6, CYP46, SERPINA3 and PPARγ. 2006.
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80 Marina Boccardi: MRI studies in frontotemporal dementia. 2006. 
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79 Giedrius Kalesnykas: Cholinergic neurons of the rodent basal forebrain and their content of estrogen receptor alpha. 2005.
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78 Jouni Ihalainen: Regulation of dopamine release in the forebrain by alpha2 adrenoceptors and NMDA glutamate receptors. 2005. 
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77 Susan Iivonen: Genetic and expressional studies of Alzheimer's disease candidate genes. Emphasis on CYP19, seladin-1 and HSPG2 genes. 2005.
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76 Iain Wilson: Hippocampal place cells as a window into cognitive aging. 2005.
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75 Laura Parkkinen: Impact of alfa-synuclein pathology on aging. 2005.
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74 Sinikka Peurala: Rehabilitation of gait in chronic stroke patients. 2005.
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73 Dimitrije Jakovljevic: The roles of chronobiological and socioeconomic factors in the occurrence of cerebrovascular diseases. 2005.
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72 Chuan-sheng Zhao: Psychotrophic medication and functional recovery following cortical stroke in aged rats. 2005.
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71 Maija Pihlajamäki: Functional MRI studies on human declarative memory. 2004.
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70 Erkki Kuusisto: Role of the p62 protein in the formation of neuropathological cytoplasmic inclusions. 2004.
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69 Jaana Autere: Genetics of Parkinson’s disease in the finnish population. 2003.
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68 Johanna Kuhmonen: Neuroprotection in experimental acute cerebral ischaemia. 2003.
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67 Juhana Aura: Interaction of muscarinic acetylcholine and N-methyl-D-aspartate-type glutamate receptors in the regulation of spatial learning and memory. 2003.
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66 Jun Wang: The role of Ab-peptide on spatial memory, EEG, auditory evoked potentials and nicotinic cholinergic receptors in A/P transgenic mice. 2003.
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65 Li Liu: Cholinergic neurotransmission, amyloid-b peptide and the pathogenesis of Alzheimer’s disease. A study in the APP and PS1 double transgenic mouse model. 2003.
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64 Marja Äikiä: Verbal memory in newly diagnosed partial epilepsy. A neuropsychological study. 2002.
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63 Margit Overmyer: Gliosis in relation to Alzheimer’s hallmark lesions in aging and Alzheimer’s disease. A postmortem immunohistochemical study. 2002.
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62 Miia Kivipelto: Vascular risk factors in Alzheimer’s disease and mild cognitive impairment: a longitudinal, population-based study. 2002.

61 Pauliina Korhonen: Gene regulation in neuronal degeneration - role of mSin3 and YY1 factors. 2002.
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60 Inga Kadish: Plasticity in the entorhinal-hippocampal pathway. Influences of gene mutations and hormones. 2002.
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59 Maaria Ikonen: Apoptosis-associated changes in neuronal gene expression. With special emphasis on the insulin-like growth factor system. 2001.
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58 Kirsi Puurunen: The effects of pharmacotherapy and training on functional recovery after global and focal cerebral ischemia in rats. 2001.
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57 Tero Tapiola: Biological markers for Alzheimer’s disease. With special emphasis on cerebrospinal fluid b-amyloid and tau. 2001.
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56 Zinayida Bezvenyuk: Multiple pathways of DNA disintegration during neuronal apoptosis. 2001.
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55 Tuuli Salmenperä: Damage in the hippocampus, amygdala, entorhinal and perirhinal cortex of adults with partial epilepsy. 2001.
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54 Sami Ikonen: The role of the septohippocampal cholinergic system in cognitive functions. 2001.
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53 Mikko Hiltunen: A molecular genetic study of factors involved in Alzheimer’s disease. 2000.
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52 Kauko Pitkänen: Stroke rehabilitation in the elderly. A controlled study of the effectiveness and costs of a multidimensional intervention. 2000.
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51 Jukka Puoliväli: An experimental study on the cholinergic modulation of cortical arousal and cognitive functions. With special emphasis on apolipoprotein E. 2000.
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50 Mia Mikkonen: The human entorhinal cortex: anatomic organization and its alteration in Alzheimer’s disease and temporal lobe epilepsy. 1999.
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49 Tarja Puumala: Monoamines in the modulation of attention and response inhibition: development of a new animal model of attention deficit and impulsivity. 1999.

48 Raimo Pussinen: An experimental study on the role of alpha₁-adrenoceptors and putrescine in the modulation of hippocampal plasticity and memory encoding - Interactions with NMDA receptors. 1999.

47 Kirsi Juottonen: MRI volumes of the entorhinal, perirhinal and temporopolar cortices in normal aging and Alzheimer's disease. 1998.

46 Matti Vanhanen: Cognitive function in glucose intolerance in the elderly: the role of hyperinsulinemia. 1998.
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45 Merja Hallikainen: Age-associated memory impairment, and apolipoprotein E. A population-based clinical, neuropsychological, neurophysiological, and neuroimaging study. 1998.
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44 Seppo Helisalmi: Molecular genetics of Alzheimer’s disease. With special emphasis on presenilin, amyloid beta precursor protein and apolipoprotein E genes. 1998.
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43 Sirja Ruotsalainen: Serotonergic system and its interactions with cholinergic receptor mediated mechanisms in the modulation of working memory. An experimental study. 1997.

42 Tiina Kotti: Excitotoxicity-induced neuropathological changes in the rodent hippocampus. Possible functional consequences and drug treatments. 1997.

41 Heikki Sorvari: Neurons containing calcium-binding proteins in the human amygdaloid complex. 1997.

 40 Vesa Savander: Organization of intrinsic connections in the rat amygdaloid complex. With special emphasis on the lateral, basal and accessory basal nuclei. 1997.

39 Tuomo Hänninen: Age-associated memory impairment. A neuropsychological and epidemiological study. 1996.
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38 Maarit Lehtovirta: Familial Alzheimer’s disease. A clinical and molecular genetic study. 1996.

37 Mikko Laakso: MRI of hippocampus in incipient Alzheimer’s disease. 1996. pdf htm

36 Olli Kosunen: A neuropathologic study on Alzheimer’s disease with a special emphasis on diagnostic accuracy. 1996.

35 Mervi Pitkänen: The role and pharmacological modulation of the NMDA receptor/channel on hippocampal synaptic transmission and behavior. 1995.

34 Arja Tuunainen: Evaluation of epileptic patients for temporal lobe surgery and postoperative follow-up. An electrophysiological study with neuropsychological, psychiatric and clinical correlates. 1995.

33 Keijo Koivisto: Population-based dementia screening program in the city of Kuopio, Eastern Finland: Evaluation of screening methods, prevalence of dementia and dementia subtypes. 1995.

32 Minna Riekkinen: The interaction between cholinergic and serotononergic systems in the modulation of spatial navigation and passive avoidance behavior. 1994.

31 Outi Heinonen: Neuropathological and peripheral markers of Alzheimer’s disease with special emphasis on b-amyloid accumulation. 1994.

30 Päivi Hartikainen: Normal ageing. A neurochemical, neurophysiological and neuropsychological study with special reference to Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. 1994.

29 Hannele Lahtinen: Hippocampus in experimental models of temporal lobe epilepsy. Amino acid mediated neurotransmission and nerve cell injury following the transsection of fimbria-fornix and electrical stimulation of perforant pathway in rat. 1993.

28 Riitta Miettinen: Inhibitory circuits and subcortical innervation of the rat hippocampus: Implications for normal function and pathophysiological processes. 1993.

27 Kari Alhainen: Anticholinesterase drug, tacrine (THA), in Alzheimer’s disease. Discrimination of responders and nonresponders. 1992.

26 Pekka Jäkälä: Modulation of attention and working memory by noradrenergic, serotonergic and cholinergic systems. An experimental neuropsychopharmacological study. 1992.

25 Maria Mazurkiewicz: The effects of enhanced GABAergic transmission on cognitive functions: An experimental study. 1992.

24 Reetta Kälviäinen: Newly diagnosed epileptic seizure disorder in adults. A prospective follow-up study on 100 patients. 1992.

23 Aimo Rissanen: Cerebrovascular disease in Jyväskylä region, Central Finland. 1992.

22 Antti Valjakka: The subcortical afferentation of the hippocampus and noradrenergic lesions as experimental models of dementia. 1992.

21 Aarne Ylinen: Hippocampal reactions and their pharmacotherapy in experimental epilepsy. 1991.

20 Kari Murros: Stress reactions of brain infarction. A prospective study on 105 patients with acute ischemic brain infarction of internal carotid artery territory. 1991.

19 Ulla Lepola: Panic disorder. A clinical, neurochemical, neuropsychological and neuroradiological study. 1990.

18 Toivo Halonen: Neurotransmitter amino acids in epileptic convulsions and during vigabatrin treatment. 1990.

17 Paavo Riekkinen Jr.: Animal models of age-related degeneration of subcortical regulatory system. With special reference to cholinergic, noradrenergic and serotonergic systems. 1990.

16 -

15 Eeva-Liisa Helkala: Memory in patients with Alzheimer’s disease and demented patients with Parkinson’s disease. 1990.

14 Asla Pitkänen: Somatostatin in experimental and human epilepsy. 1989.

13 Hannu Koponen: Delirium in the elderly. A clinical, neurochemical, neurophysiological and neuroradiological study. 1989.

12 Jouni Sirviö: The cholinergic system in ageing and dementia. With special reference to acetylcholinesterase. 1989.

11 Jukka Jolkkonen: Vasopressin in the central nervous system. A study based on cerebrospinal fluid measurements. 1988.

10 Tapani Keränen: Epilepsy in adults. An epidemiological study in Eastern Finland. 1988.

9 Kari Reinikainen: Neurotransmitters in Alzheimer’s disease. 1988.

8 Esa Mervaala: Evoked potential in human epilepsy. A neurophysiological study. 1987.

7 Asla Pitkänen: Somatostatin in epilepsy. An experimental and clinical study. 1987.

6 Juhani Sivenius: Studies on rehabilitation, epidemiology and clinical features of stroke in East Central Finland. 1982.

5 Markku Saksa: The autonomic nervous system in experimental allergic neuritis. A functional, morphological and biochemical study. 1982.

4 Rolf Danner: Adverse effects of anticonvulsive treatment on peripheral nerve conduction and posterior dominant EEG rhythm. 1982.

3 Hilkka Soininen: Senile dementia. A clinical, neurochemical and etiological study. 1981.

2 Eeva Leino: Clinical and biochemical studies on progressive myoclonus epilepsy. 1981.

1 Juhani Partanen: Time-locked phenomena of human motor unit potentials. An electromyographic study of satellites and doubles. 1979.