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Field responses to perforant path stimulation in the hippocampus in vivo

Hippocampal place field firing rate maps in a familiar and a new environment

A mouse in the water maze in the search for the hidden platform

     
      Cognitive Neuroscience | People | Publications

      Research Director Heikki Tanila

      Research interests

      • Neuronal correlates of memory encoding and retrieval in the hippocampus
      • Neurobiological basis of memory loss in Alzheimer’s disease
      • Neurobiological basis of age-associated memory impairment
      Subjects
      • Young and aged rats
      • Transgenic mice carrying human APP and PS1 mutations as a model of Alzheimer’s disease
      • Transgenic rats carrying human tau mutation as a model of Alzheimer’s disease
      • Transgenic mice with alpha synuclein pathology as a model of Lewy body dementia
      Methods
      • Behavioral assessment of learning and memory in rats and mice
      • Behavioral screening of transgenic mice
      • Electrophysiological recordings of EEG and ERPs in freely moving rodents
      • Electrophysiological recordings of hippocampal single units (place cells) in freely moving rodents
      • Induction and recording of hippocampal LTP in vivo and in vitro 
      • In vivo microdialysis in freely moving rats and mice
      • Determination of brain monoamines with HPLC
      • Determination of AChE activity
      • Determination of Aß peptides with ELISA from brain and CSF samples