Research Interests
- Ion mobility spectrometry (IMS) in monitoring of hazardous compounds
- Reagent gas chemistry
- IMS technology in quantitative analysis of toxic industrial chemicals
- Preconcentrators and sampling techniques for IMS
On going Research Projects
Monitoring the quality of waters and waste waters is important in
protecting public health and environment. Various parameters are already in
use for the determination of different contaminants from waters. However, an
increase in environmental pollution and/or increase in public awareness and
understanding in health related issues has resulted need to develop better,
faster, and more sustainable methods to study toxic substances from
contaminated water as well as to monitor the quality of treated water.
My present research is focused on investigating the suitability and
technical potential of IMS as an early warning system for monitoring
volatile toxic chemicals in municipal waters and waste waters as well as in
industrial wastewater. The compounds of interest include fuel based
compounds such as methyl tert-butyl ether (MTBE). The project will
contribute to the development of novel strategies in water quality control
and strengthening of environmental management in terms of water monitoring.
Latest poster of this project
SPME_IMS_poster.pdf
Main partners in co-operation/Funding
- Environics Oy
- The Academy of Finland
Publications in peer reviewed journals
Nousiainen, M., Rafn, K., Skou, L., Roepstorff, P., Andersen, S.O.
(1998). Characterization of Exoskeletal Proteins from the American Lobster,
Homarus Americanus. Comp. Biochem. Physiol. 119B, 189-199.
Nousiainen, M., Vainiotalo, P., Feng, X., Derrick, P.J. (2001).
Calmodulin-RS20-Ca4 Complex in the Gas Phase: Electrospray Ionisation and
Fourier Transform Ion Cyclotron Resonance. Eur. J. Mass Spectrom. 7,
393-398.
Nousiainen, M., Derrick, P.J., Kaartinen, M.T., Mäenpää, P.H., Rouvinen,
J., Vainiotalo, P. (2002). A Mass Spectrometric Study of Metal Binding to
Osteocalcin. Chem. Biol. 9, 195-202.
Nousiainen, M., Cooper, H.J., Fati, D., Hoxha, A., Trayer, H.R., Ward,
D.G., Vainiotalo, P., Derrick, P.J., Trayer, I.P. (2002). Calcium and
Peptide Binding to Folded and Unfolded Conformations of Cardiac Troponin C.
Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass
Spectrometry. Eur. J. Mass Spectrom. 8, 471-481.
Nousiainen, M., Derrick, P.J., Lafitte, D., Vainiotalo, P. (2003).
Relative Affinity Constants by Electrospray Ionization and Fourier Transform
Ion Cyclotron Resonance Mass Spectrometry: Calmodulin Binding to Peptide
Analogues of Myosin Light Chain Kinase. Biophys. J. 85, 491-500.
Grimmler, M., Martin, L., Nousiainen, M., Körner, R., Meister, G.,
Fischer, U. (2005). Phosphorylation Regulates the Activity of the
SMN-complex During Assembly of Spliceosomal U snRNPs. EMBO Reports, 6,
70-76.
Chan, E.H.Y., Nousiainen, M., Chalmalasetty, R.B., Schäfer, A., Nigg, E.A.,
Silljé, H.H.W. (2005). The Ste20-like Kinase Mst2 Activates the Human Large
Tumor Suppressor Kinase Lats1. Oncogene, 24, 2076-2086.
Nousiainen, M., Silljé, H.H.W., Sauer, G., Nigg, E.A., Körner, R. (2006).
Phosphoproteome Analysis of the Human Mitotic Spindle. Proc. Natl. Acad. Sci.
USA, 103, 5391-5396.
Nousiainen, M., Peräkorpi, K., Sillanpää, M. (2007). Determination of
Gas-Phase Produced Ethyl Parathion and Toluene 2,4-Diisocyanate by Ion
Mobility Spectrometry, Gas Chromatography and Liquid Chromatography. Talanta,
72, 984-990.
Räsänen, R.-M., Nousiainen, M., Peräkorpi, K., Sillanpää, M., Polari, L.,
Anttalainen, O. and Utriainen, M. (2008). Determination of Gas Phase
Triacetone Triperoxide with Aspiration Ion Mobility Spectrometry and Gas
Chromatography-Mass Spectrometry. Anal. Chim. Acta, 623, 59-65.
Puton, J., Nousiainen, M., Sillanpää, M. (2008). Ion Mobility
Spectrometers with Doped Gases. Talanta, 76, 978-987. |
