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Molecular Brain Research
The Laboratory of Molecular Brain Research investigates inflammatory mechanisms
of neurodegeneration focusing on models of three different diseases, stroke (acute
neurodegeneration), Alzheimer's disease and amyotrophic lateral sclerosis (chronic
neurodegenerative diseases). We use several animal models of the diseases and
utilize genetically modified mouse strains and cells both in vivo and in vitro.
The idea is to investigate the role of key (inflammatory or cell death-promoting)
enzymes at the molecular and cellular level and verify their significance in
pathogenesis of the animal models of the brain diseases. Eventually, we try to
obtain information from the human material of these diseases to understand the
clinical relevance of these key enzymes.
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A.I. Virtanen Institute for Molecular Sciences, Department of Neurobiology,
P.O. Box 1627, FI-70211 Kuopio, FINLAND; Visiting address: Neulaniementie 2;
Phone +358 207 87 2211;
Fax +358 17 163 030; E-mail: aivi@uku.fi
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