Molecular Medicine

We will develop new gene and protein-based approaches for the treatment of cardiovascular diseases and malignant glioma. Major achievements include the discovery of the vasculoprotective effect of VEGF gene therapy, characterization of the vascular effects of  the members of the VEGF family (VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, VEGF-F and their receptors) and identification of several new candidate genes for the treatment of vascular diseases. Also, several significant improvements have been made to adenoviral, lentiviral and baculoviral gene transfer vectors. Two of our discoveries in gene-based drugs have been brought to phase II/III human clinical trials in EU and USA.